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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HCN1 All Species: 23.64
Human Site: S245 Identified Species: 65
UniProt: O60741 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O60741 NP_066550.2 890 98796 S245 I V E K G M D S E V Y K T A R
Chimpanzee Pan troglodytes XP_526930 460 51719
Rhesus Macaque Macaca mulatta XP_001092625 537 59913
Dog Lupus familis XP_855255 901 99693 S238 I V E K G M D S E V Y K T A R
Cat Felis silvestris
Mouse Mus musculus O88704 910 102413 S234 I V E K G M D S E V Y K T A R
Rat Rattus norvegicus Q9JKB0 910 102403 S234 I V E K G M D S E V Y K T A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_425050 1188 129247 S337 I V E T R I D S E V Y K T A R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_685414 901 101015 S259 I V E K G I D S E V Y K T A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24278 665 75805 S85 A M E D A A L S S E I R G S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.8 58.4 94 N.A. 93.1 93.3 N.A. N.A. 49 N.A. 60.5 N.A. 20.6 N.A. N.A. N.A.
Protein Similarity: 100 50.4 59.5 95.2 N.A. 94 94.4 N.A. N.A. 57.8 N.A. 70.3 N.A. 38.5 N.A. N.A. N.A.
P-Site Identity: 100 0 0 100 N.A. 100 100 N.A. N.A. 80 N.A. 93.3 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 0 0 100 N.A. 100 100 N.A. N.A. 86.6 N.A. 100 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 0 12 12 0 0 0 0 0 0 0 67 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 12 0 0 67 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 78 0 0 0 0 0 67 12 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 56 0 0 0 0 0 0 0 12 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 67 0 0 0 0 23 0 0 0 0 12 0 0 0 0 % I
% Lys: 0 0 0 56 0 0 0 0 0 0 0 67 0 0 0 % K
% Leu: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % L
% Met: 0 12 0 0 0 45 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 12 0 0 0 0 0 0 12 0 0 67 % R
% Ser: 0 0 0 0 0 0 0 78 12 0 0 0 0 12 12 % S
% Thr: 0 0 0 12 0 0 0 0 0 0 0 0 67 0 0 % T
% Val: 0 67 0 0 0 0 0 0 0 67 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 67 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _